This study examined knowledge, attitude, prevalence, and factors affecting cigarette smoking among male students of a university in Bangladesh. A cross-sectional survey was conducted on 474 students in 2009. Both quantitative and qualitative statistics were employed to examine the relationship between smoking and sociopsychological factors. Overall, 36.1% of the students were currently smoking. Significantly, more nonsmokers than smokers showed negative attitudes toward smoking and positive attitudes toward tobacco-controlling measures. Age, study streams and year, mother's education and occupation, monthly expenditure, and father's smoking appeared as important determinants of students' smoking. A multivariate logistic regression analysis yielded significantly (P < .001) increased risk of smoking among students of the Law and Shariah Faculty (odds ratio [OR] = 38.75, 95% confidence interval [CI] = 6.56-228.82), third-year students (OR = 7.18,95% CI = 2.56-20.17), and urban residents (OR = 2.14, 95% CI = 1.26-3.63). There is an urgent need for health promotion and antitobacco education in building a tobacco-free nation.