Prima-1met Induces Cytotoxicity in Multiple Myeloma Cells Irrespective of p53 Status and Displays a Synergistic Cytotoxic Response with Conventional Chemotherapeutic Drugs

被引:0
|
作者
Jiang, H. [1 ]
Saha, M. N. [1 ]
Chen, M-H [1 ]
Chang, H. [1 ]
机构
[1] Univ Hlth Network, Toronto, ON, Canada
关键词
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
1286
引用
收藏
页码:302A / 303A
页数:2
相关论文
共 50 条
  • [1] Prima-1met Induces Cytotoxicity in Multiple Myeloma Cells Irrespective of p53 Status and Displays a Synergistic Cytotoxic Response with Conventional Chemotherapeutic Drugs
    Jiang, H.
    Saha, M. N.
    Chen, M-H
    Chang, H.
    LABORATORY INVESTIGATION, 2011, 91 : 302A - 303A
  • [2] RITA Induces Cytotoxicity and Apoptosis in Multiple Myeloma Cells Harbouring Wild Type p53: Evidence for Synergistic Cytotoxic Responses with Conventional Chemotherapeutic Drugs
    Saha, M. N.
    Jiang, H.
    Branch, D. R.
    Chang, H.
    MODERN PATHOLOGY, 2011, 24 : 319A - 319A
  • [3] RITA Induces Cytotoxicity and Apoptosis in Multiple Myeloma Cells Harbouring Wild Type p53: Evidence for Synergistic Cytotoxic Responses with Conventional Chemotherapeutic Drugs
    Saha, M. N.
    Jiang, H.
    Branch, D. R.
    Chang, H.
    LABORATORY INVESTIGATION, 2011, 91 : 319A - 319A
  • [4] The p53 Reactivating Drug PRIMA-1Met Induces Apoptosis Of Myeloma Cells Via ROS Production
    Tessoulin, Benoit
    Descamps, Geraldine
    Godon, Catherine
    Bene, Marie C.
    Moreau, Philippe
    Le Gouill, Steven
    Amiot, Martine
    Pellat-Deceunynck, Catherine
    BLOOD, 2013, 122 (21)
  • [5] Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status
    Patyka, Mariia
    Sharifi, Zeinab
    Petrecca, Kevin
    Mansure, Jose
    Jean-Claude, Bertrand
    Sabri, Siham
    ONCOTARGET, 2016, 7 (37) : 60245 - 60269
  • [6] PRIMA-1Met induces apoptosis in Waldenstrom's Macroglobulinemia cells independent of p53
    Sobhani, Mona
    Abdi, Jahangir
    Manujendra, Saha N.
    Chen, Christine
    Chang, Hong
    CANCER BIOLOGY & THERAPY, 2015, 16 (05) : 799 - 806
  • [7] PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
    Tessoulin, Benoit
    Descamps, Geraldine
    Moreau, Philippe
    Maiga, Sophie
    Lode, Laurence
    Godon, Catherine
    Marionneau-Lambot, Severine
    Oullier, Thibauld
    Le Gouill, Steven
    Amiot, Martine
    Pellat-Deceunynck, Catherine
    BLOOD, 2014, 124 (10) : 1626 - 1636
  • [8] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
    J M R Lambert
    A Moshfegh
    P Hainaut
    K G Wiman
    V J N Bykov
    Oncogene, 2010, 29 : 1329 - 1338
  • [9] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
    Lambert, J. M. R.
    Moshfegh, A.
    Hainaut, P.
    Wiman, K. G.
    Bykov, V. J. N.
    ONCOGENE, 2010, 29 (09) : 1329 - 1338
  • [10] Small Molecule PRIMA-1met Induces Apoptosis in Waldenstrom Macroglobulinemia Cells and Exhibits a Synergistic Cytotoxic Response with Dexamethasone
    Kwan, K.
    Saha, M. N.
    Koh, S.
    Zhang, L.
    Chen, C.
    Chang, H.
    LABORATORY INVESTIGATION, 2013, 93 : 339A - 339A