Thyroid function changes and cytokine alterations following major surgery

被引：10

作者：

Ilias, Ioannis ^{[1
]}

Tzanela, Marinella ^{[2
]}

Mavrou, Irini ^{[4
]}

Douka, Evangelia ^{[4
]}

Kopterides, Petros ^{[4
]}

Armaganidis, Apostolos ^{[4
]}

Orfanos, Stylianos ^{[4
]}

Kostopanagiotou, Georgia ^{[4
]}

Macheras, Anastasios ^{[5
]}

Tsagarakis, Stylianos ^{[3
]}

Dimopoulou, Ioanna ^{[4
]}

机构：

[1] Elena Venizelou Hosp, Dept Endocrinol, Athens, Greece

[2] Evagelismos Hosp, Athens, Greece

[3] Univ Athens, Sch Med, Athens Polyclin, GR-11527 Athens, Greece

[4] Univ Athens, Sch Med, Dept Crit Care Med 2, GR-11527 Athens, Greece

[5] Univ Athens, Sch Med, Dept Surg 3, GR-11527 Athens, Greece

来源：

NEUROIMMUNOMODULATION | 2007年 / 14卷 / 05期

关键词：

cytokine levels; surgical stress; thyroid hormones;

D O I：

10.1159/000112049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To establish whether cytokine release is implicated in thyroid hormone changes during surgical stress we studied 36 adult patients (20 men; mean age +/- SD: 68.5 +/- 10.5 years) undergoing elective major abdominal operations. We measured tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8 and IL-10 and thyrotropin (TSH), free thyroxine (FT 4) and triiodothyronine (T 3) before scheduled non-emergency surgery, immediately postoperatively, on the 1st postoperative day (post-1) and on the 2nd postoperative day (post-2). TNF alpha, IL-6 and IL-8 peaked on day post-1 whereas IL-10 peaked immediately postoperatively. Fourteen of 36 patients had low T 3 levels after surgery, indicating non-thyroidal illness (NTI). Significant negative correlations were noted among TNF-alpha, IL-6 and IL-8 against T-3 and FT4. Cytokines are responsible, at least in part, for NTI following major operations. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：243 / 247

页数：5

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