A facile synthesis of naturally occurring 5-(3-indolyl)oxazoles

被引：36
|
作者：
Kumar, Dalip [1 ]
Sundaree, Swapna [1 ]
Patel, Gautam [1 ]
Rao, V. S. [1 ]
机构：
[1] Birla Inst Technol & Sci, Chem Grp, Pilani 333031, Rajasthan, India
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 05期
关键词：
5-(3-indolyl)oxazoles; hydroxy(tosyloxy)-iodobenzene; alpha-acylaminoketones; p-toluenesulfonic-acid;
D O I：
10.1016/j.tetlet.2007.11.173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthesis of naturally occurring 5-(3-indolyl)oxazoles is described. The key steps of this convergent approach are the formation of a 3-tosyloxyacetyl-1-benzenesulfonylindole, a 3-amino-acetyl-l-benzenesulfonylindole hydrochloride and cyclodehydration of an alpha-acylaminoketone. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：867 / 869
页数：3
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