Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes

被引：28
|
作者：
Skorokhod, Oleksii A. [1 ,2 ]
Kulikova, Elena V. [1 ]
Galkina, Ninel M. [1 ]
Medvedev, Pavel V. [1 ]
Zybunova, Elena E. [1 ]
Vitvitsky, Victor M. [1 ]
Pivnik, Aleksandr V. [1 ]
Ataullakhanov, Fazoil I. [1 ]
机构：
[1] Russian Acad Med Sci, Natl Res Ctr Hematol, Moscow, Russia
[2] Univ Turin, Sch Med, Dept Genet Biol & Biochem, Via Santena 5 Bis, I-10126 Turin, Italy
来源：
HAEMATOLOGICA | 2007年 / 92卷 / 04期
关键词：
doxorubicin; carrier erythrocytes; pharmacokinetics; lymphoma;
D O I：
10.3324/haematol.10770
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.
引用
收藏
页码：570 / 571
页数：2
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