Fluctuations of temporal contrast in laser speckle imaging of blood flow

被引:15
|
作者
Hong, Jiachi [1 ,2 ]
Wang, Yang [1 ,2 ]
Chen, Xiao [1 ,2 ]
Lu, Jingling [1 ,2 ]
Li, Pengcheng [1 ,2 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Sch Engn Sci, Collaborat Innovat Ctr Biomed Engn, MoE Key Lab Biomed Photon, Wuhan 430074, Hubei, Peoples R China
[3] HUST Suzhou Inst Brainsmat, Suzhou 215125, Peoples R China
基金
中国国家自然科学基金;
关键词
NOISE;
D O I
10.1364/OL.43.005214
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Laser speckle contrast imaging can be used to estimate changes in blood flow velocity in either the spatial or temporal domain. Temporal speckle contrast analysis provides higher spatial resolution than spatial speckle contrast does. However, owing to limitations of the statistical sample size in practical applications, the speckle contrast obtained consistently fluctuates around an accurate value. It is important to reveal the quantitative relationship between the statistical sample size and fluctuations of temporal speckle contrast. In this Letter, we present a new model for temporal speckle contrast that accounts for the effects of statistical size owing to the finite frames of the speckle images used for temporal analysis. Furthermore, an expression for estimating the fluctuations of temporal speckle contrast is derived. Both phantom and animal experiment results support our theoretical model. (C) 2018 Optical Society of America
引用
收藏
页码:5214 / 5217
页数:4
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