Severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues

被引：25

作者：

Carr, JF ^{[1
]}

Gregory, ST ^{[1
]}

Dahlberg, AE ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 10期

关键词：

D O I：

10.1128/JB.187.10.3548-3550.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The structural basis for the streptomycin dependence phenotype of ribosomal protein S12 mutants is poorly understood. Here we describe the application of site-directed mutagenesis and gene replacement of Thermus thermophilus rpsL to assess the importance of side chain identity and tertiary interactions as phenotypic determinants of drug-dependent mutants.

引用

页码：3548 / 3550

页数：3

共 15 条

[1] Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12
Carr, JF
Hamburg, DM
Gregory, ST
Limbach, PA
Dahlberg, AE
JOURNAL OF BACTERIOLOGY, 2006, 188 (05) : 2020 - 2023
[2] RIBOSOMAL-PROTEIN S12 AS A SITE FOR STREPTOMYCIN RESISTANCE IN NICOTIANA CHLOROPLASTS
GALILI, S
FROMM, H
AVIV, D
EDELMAN, M
GALUN, E
MOLECULAR AND GENERAL GENETICS, 1989, 218 (02): : 289 - 292
[3] Novel streptomycin-resistance mutations in ribosomal protein S12 suggest an interaction with the ternary complex during decoding
Carr, JF
Gregory, ST
Dahlberg, AE
FASEB JOURNAL, 2004, 18 (08): : C145 - C145
[4] A kirromycin-resistant EF-Tu species reverses streptomycin dependence of Escherichia coli strains mutated in ribosomal protein S12
Zuurmond, AM
Zeef, LAH
Kraal, B
MICROBIOLOGY-UK, 1998, 144 : 3309 - 3316
[5] ALTERED SURFACE PROPERTIES OF ESCHERICHIA-COLI ASSOCIATED WITH A SPECIFIC AMINO-ACID CHANGE IN S12 RIBOSOMAL-PROTEIN OF STREPTOMYCIN-RESISTANT MUTANTS
PESTKA, S
WALTER, H
WAYNE, LG
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (06) : 978 - 983
[6] RIBOSOMAL-PROTEINS .33. LOCATION OF AMINO-ACID REPLACEMENTS IN PROTEIN S12 ISOLATED FROM ESCHERICHIA-COLI MUTANTS RESISTANT TO STREPTOMYCIN
FUNATSU, G
WITTMANN, HG
JOURNAL OF MOLECULAR BIOLOGY, 1972, 68 (03) : 547 - &
[7] AMINO-ACID REPLACEMENTS IN PROTEINS S5 AND S12 OF 2 ESCHERICHIA-COLI REVERTANTS FROM STREPTOMYCIN DEPENDENCE TO INDEPENDENCE
ITOH, T
WITTMANN, HG
MOLECULAR & GENERAL GENETICS, 1973, 127 (01): : 19 - 32
[8] Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
Shima, J
Hesketh, A
Okamoto, S
Kawamoto, S
Ochi, K
JOURNAL OF BACTERIOLOGY, 1996, 178 (24) : 7276 - 7284
[9] Streptomycin affinity depends on 13 amino acids forming a loop in homology modelled ribosomal S12 protein (rpsL gene) of Lysinibacillus sphaericus DSLS5 associated with marine sponge (Tedania anhelans)
Suriyanarayanan, Balasubramanian
Lakshmi, Praveena Pothuraju
Santhosh, Ramachandran Sarojini
Dhevendaran, Kandasamy
Priya, Balakrishnan
Krishna, Shivaani
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2016, 34 (06): : 1190 - 1200
[10] STREPTOMYCIN RESISTANCE AND RIBOSOMAL-PROTEINS - AMINO-ACID SUBSTITUTIONS IN STR PROTEIN OF ONE STREPTOMYCIN-RESISTANT MUTANT OF ESCHERICHIA-COLI-K12 AFTER MUTAGENESIS WITH ETHYL METHANESULFONATE
BRAKIERGINGRAS, L
LACOSTE, L
BOILEAU, G
CANADIAN JOURNAL OF BIOCHEMISTRY, 1974, 52 (04): : 304 - 309

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