Subcutaneous immunoglobulin therapy for the treatment of multifocal motor neuropathy: a case report

被引:25
|
作者
Dacci, Patrizia [1 ]
Riva, Nilo [2 ]
Scarlato, Marina [2 ]
Andresen, Irmgard [4 ]
Schmidt, DirkSteffen [5 ]
Comi, Giancarlo [2 ,3 ]
Fazio, Raffaella [2 ]
机构
[1] Ist Sci San Raffaele, Dept Neurol, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, Inst Expt Neurol INSPE, Dept Neurol, I-20132 Milan, Italy
[3] Univ Vita & Salute San Raffaele, Dept Neurol, Milan, Italy
[4] CLS Behring, Bern, Switzerland
[5] CLS Behring, Marburg, Germany
关键词
Multifocal motor neuropathy; Disimmune peripheral neuropathy; Intravenous immunoglobulin; Subcutaneous immunoglobulin; PRIMARY ANTIBODY DEFICIENCIES; INTRAVENOUS IMMUNOGLOBULIN; SELF-INFUSIONS; GLOBULIN; TRIAL; HOME;
D O I
10.1007/s10072-010-0352-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multifocal motor neuropathy (MMN) is a rare immune-mediated disease characterized by slowly progressive, asymmetric, predominantly distal weakness of one or more limbs without sensory loss. The first line of treatment is high-dose intravenous immunoglobulins (IVIg). Subcutaneous immunoglobulins (SCIg)already approved for the treatment of primary immune deficiency have recently been proposed also for the treatment of disimmune peripheral neuropathies such as MMN, and a few trials were performed to see if patients receiving immunomodulatory doses of IVIg could be treated equally well with SCIg. We describe a patient affected by MMN who was included in a protocol of treatment with SCIg for a period of 6 months. He successfully responded to treatment with a stabilization of strength. The patient is still treated with SCIg even after the end of the protocol. This is the first description of an Italian case of a patient affected by MMN successfully treated with SCIg.
引用
收藏
页码:829 / 831
页数:3
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