Statistics of kinetic pathways on biased rough energy landscapes with applications to protein folding

被引：80

作者：

Wang, J ^{[1
]}

Onuchic, J ^{[1
]}

Wolynes, P ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PHYS,LA JOLLA,CA 92093

来源：

PHYSICAL REVIEW LETTERS | 1996年 / 76卷 / 25期

关键词：

D O I：

10.1103/PhysRevLett.76.4861

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Using path integrals, the statistics of kinetic pathways on a biased random energy landscape can be mapped on to the statistical mechanics of the random directed polymer. Using this, we make explicit the role of time scales in defining a protein folding pathway and the connections between thermodynamic glass transitions of the protein and the emergence of discrete kinetic pathways for folding.

引用

页码：4861 / 4864

页数：4

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