Embedded Codes for Reassembling Non-Overlapping Random DNA Fragments

被引:3
|
作者
Nassirpour, Sajjad [1 ]
Vahid, Alireza [1 ]
机构
[1] Univ Colorado, Dept Elect Engn, Denver, CO 80204 USA
关键词
DNA; Sequential analysis; Biological information theory; Encoding; Decoding; Channel models; Memory; DNA storage; Varshamov-Tenengolts code; DIGITAL INFORMATION; GENE SYNTHESIS; BREAK REPAIR; STORAGE; ROBUST;
D O I
10.1109/TMBMC.2020.3035370
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We consider the problem of recovering the stored data from randomly broken Deoxyribonucleic Acid (DNA) fragments. More precisely, we assume a channel that breaks the DNA into a random number of non-overlapping fragments where the length of each fragment comes from a memoryless Geometric process. We devise an embedded code structure that enables reassembly of the DNA and analyze its error probability. We observe that the error decreases with DNA length for various breaking probabilities of the Geometric process. Our code is built upon Varshamov-Tenengolts (VT) codes, and enables a much more efficient recovery strategy compared to brute-force search among all permutations of the DNA fragments.
引用
收藏
页码:40 / 50
页数:11
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