Association between the geographic region and the risk of familial atrioventricular nodal reentrant tachycardia in the Polish population

INTRODuCTION Atrioventricular nodal reentrant tachycardia (AVNRT) is one of the most common regular supraventricular arrhythmias referred for catheter ablation (CA). In Poland, several families with familial AVNRT (FAVNRT) were reported in Podkarpacie Province (PP). OBJECTIVEs We aimed to determine the frequency of FAVNRT in PP compared with other south -eastern provinces of Poland. PATIENTs AND METHODs Clinical data of 1544 patients with AVNRT diagnosed by invasive electrophysi-ological study between 2010 and 2019 were screened for FAVNRT. From January 2017 to June 2019, patients were asked to provide details on family history and origin to obtain 3 -generation pedigrees. Families with at least 2 members with previous CA of AVNRT were divided into those from south -eastern provinces (SEPs; including PP and bordering provinces [BPs]) and the remaining parts of Poland (RPP). REsuLTs There were 932 patients from SEPs and 612 from RPP. FAVNRT was reported in 45 patients (2.91%) from 27 families, with a higher frequency in SEPs than RPP (4.02% vs 1.17%; P = 0.002) and the highest frequency in PP (6.33% vs 2.47% in BPs; P = 0.004). The risk of FAVNRT was higher in PP compared with BPs (odds ratio, 2.67; 95% CI, 1.36-5.23; P = 0.004) and similar in BPs compared with RPP (odds ratio, 2.14; 95% CI, 0.86-5.34; P = 0.1). CONCLusIONs A relationship exists between the geographic region and frequency of FAVNRT. A greater distance from PP was associated with less frequent FAVNRT. International cooperation and genetic test -ing are needed to confirm the genetic impact of FAVNRT in this part of Central Europe.