Cell-based biosensors and its application in biomedicine

Cell-based biosensors (CBBs), a research hotspot of biosensors, which treat living cells as sensing elements, can detect the functional information of biologically active analytes. They characterize with high sensitivity, excellent selectivity and rapid response, and have been applied in many fields, such as biomedicine, environmental monitoring and pharmaceutical screening. Recently cell-cultured technology, silicon microfabrication technology and genetic technology have promoted exploration of CBBs dramatically. To elucidate the novel research findings and applications of cell-based biosensors, this paper firstly review recent research approaches, secondly, introduces some of our research results of cell-based biosensors, finally, presents our future purpose and proposes the research trends. (c) 2004 Elsevier B.V. All rights reserved.