A model of cooperative effect of AMPA and NMDA receptors in glutamatergic synapses

被引：15
|
作者：
Di Maio, Vito [1 ]
Ventriglia, Francesco [1 ]
Santillo, Silvia [1 ]
机构：
[1] Ist Sci Applicate & Sistemi Intelligenti, Complesso Olivetti,Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy
来源：
COGNITIVE NEURODYNAMICS | 2016年 / 10卷 / 04期
关键词：
Glutamatergic synapse; Synaptic model; Membrane resistance; AMPA; NMDA; Synaptic plasticity; EXCITATORY POSTSYNAPTIC CURRENTS; STOCHASTIC FLUCTUATIONS; BROWNIAN SIMULATION; DENDRITIC SPINES; VARIABILITY; NONSATURATION; PROBABILITY; DIFFUSION; AMPLITUDE; INPUT;
D O I：
10.1007/s11571-016-9383-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glutamatergic synapses play a pivotal role in brain excitation. The synaptic response is mediated by the activity of two receptor types (AMPA and NMDA). In the present paper we propose a model of glutamatergic synaptic activity where the fast current generated by the AMPA conductance produces a local depolarization which activates the voltage- and [Mg2+]-dependent NMDA conductance. This cooperative effect is dependent on the biophysical properties of the synaptic spine which can be considered a high input resistance specialized compartment. Herein we present results of simulations where different values of the spine resistance and of the Mg2+ concentrations determine different levels of cooperativeness between AMPA and NMDA receptors in shaping the post-synaptic response.
引用
收藏
页码：315 / 325
页数：11
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