Copper-Catalyzed Multicomponent Trifluoromethylphosphorothiolation of Alkenes: Access to CF3-Containing Alkyl Phosphorothioates

被引：28

作者：

Zhang, Pengbo ^{[1
]}

Yu, Guo ^{[1
]}

Li, Wenwu ^{[1
]}

Shu, Zhigang ^{[1
]}

Wang, Longyu ^{[1
]}

Li, Zhaoting ^{[1
]}

Gao, Xia ^{[1
]}

机构：

[1] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 15期

关键词：

P(O)H COMPOUNDS; THIOLS; PHOSPHINOTHIOATES; PHOSPHONATES; REAGENTS; ACIDS;

D O I：

10.1021/acs.orglett.1c01985

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented copper-catalyzed multicomponent radical-based reaction involving alkenes, P(O)H compounds, sulfur powder, and Togni reagent II at room temperature has been developed. A variety of highly functionalized CF3-containing S-alkyl phosphorothioates can be directly prepared from a wide range of activated and unactivated alkenes. Moreover, this protocol highlights its potential in the late-stage functionalization of complex molecules and opens up a new avenue for the construction of C(sp(3))-S-P bonds.

引用

页码：5848 / 5852

页数：5

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