Kinetic spectrophotometric determination of famotidine in pharmaceutical preparations

被引：14
|
作者：
Walash, MI [1 ]
Sharaf-El-Din, MK [1 ]
Metwally, MES [1 ]
Shabana, MR [1 ]
机构：
[1] Univ Mansoura, Fac Pharm, Dept Analyt Chem, Mansoura 35516, Egypt
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2005年 / 52卷 / 01期
关键词：
kinetic; famotidine; fixed time;
D O I：
10.1002/jccs.200500011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A kinetic method for the accurate and sensitive determination of famotidine has been described. The method is based on the alkaline oxidation of famotidine with potassium permanganate at a fixed time of 10 min. The formed manganate ion is measured at 610 nm. The concentration of famotidine is calculated using the calibration equation for the fixed time method. Beer's law was obeyed in the range of 1-10 mu g/mL and the R.S.D. (n = 10) was 0.47 %. The method has been applied successfully to commercial tablet dosage form.
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页码：71 / 76
页数：6
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