Mechanisms of cardiac potassium channel trafficking

被引：48
|
作者：
Steele, David F. [1 ]
Eldstrom, Jodene [1 ]
Fedida, David [1 ]
机构：
[1] Univ British Columbia, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada
来源：
JOURNAL OF PHYSIOLOGY-LONDON | 2007年 / 582卷 / 01期
关键词：
D O I：
10.1113/jphysiol.2007.130245
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The regulation of ion channels involves more than just modulation of their synthesis and kinetics, as controls on their trafficking and localization are also important. Although the body of knowledge is fairly large, the entire trafficking pathway is not known for any one channel. This review summarizes current knowledge on the trafficking of potassium channels that are expressed in the heart. Our knowledge of channel assembly, trafficking through the Golgi apparatus and on to the surface is covered, as are controls on channel surface retention and endocytosis.
引用
收藏
页码：17 / 26
页数：10
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