Endogenous sodium pump inhibitors and blood pressure regulation: An update on recent progress

被引：0
|
作者：
Doris, PA
Bagrov, AY
机构：
[1] Univ Texas, Inst Mol Med, Hlth Sci Ctr, Houston, TX 77025 USA
[2] NIA, Cardiovasc Sci Lab, Baltimore, MD 21224 USA
[3] IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia
来源：
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 218卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Rapid progress has occurred recently in understanding the origin, chemistry, synthesis, control, and actions of endogenous materials that may be ligands for the cardiac glycoside binding site on the mammalian sodium pump (Na,K-ATPase), The present paper reviews this progress and examines in detail the evidence supporting ouabain-like and bufodienolide-like compounds as functioning in endogenous control of sodium pump activity, renal sodium excretion, blood pressure, and cardiovascular contractility. Other novel compounds identified in this search as potentially influencing natriuresis and blood pressure are also discussed.
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收藏
页码：156 / 167
页数：12
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