Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature

被引：40

作者：

Hiramatsu, Keiichi ^{[1
]}

Igarashi, Masayuki ^{[2
]}

Morimoto, Yuh ^{[1
]}

Baba, Tadashi ^{[1
]}

Umekita, Maya ^{[2
]}

Akamatsu, Yuzuru ^{[2
]}

机构：

[1] Juntendo Univ, Dept Bacteriol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Microbial Chem Res Fdn, Inst Microbial Chem, Tokyo, Japan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 39卷 / 06期

关键词：

Quinolone resistance; gyrA mutations; Reverse antibiotic; Nybomycin; VISA; VRSA; STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; TOPOISOMERASE-IV; DNA GYRASE; GENOME; FLUOROQUINOLONE; QUINOLONES; MUTANTS; STRAIN;

D O I：

10.1016/j.ijantimicag.2012.02.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (<1 x 10(-11)/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'. (c) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：478 / 485

页数：8

共 50 条

[1] Non-antibiotics Reverse Resistance of Bacteria to Antibiotics
Kristiansen, J. E.
Thomsen, V. F.
Martins, Ana
Viveiros, M.
Amaral, L.
[J]. IN VIVO, 2010, 24 (05): : 751 - 754
[2] The role of antibiotics and antibiotic resistance in nature
Aminov, Rustam I.
[J]. ENVIRONMENTAL MICROBIOLOGY, 2009, 11 (12) : 2970 - 2988
[3] The multifaceted roles of antibiotics and antibiotic resistance in nature
Sengupta, Saswati
Chattopadhyay, Madhab K.
Grossart, Hans-Peter
[J]. FRONTIERS IN MICROBIOLOGY, 2013, 4
[4] The multiple roles of antibiotics and antibiotic resistance in nature
Walsh, Fiona
[J]. FRONTIERS IN MICROBIOLOGY, 2013, 4
[5] Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria
Su, Ting
Qiu, Ye
Hua, Xuesi
Ye, Bi
Luo, Haoming
Liu, Da
Qu, Peng
Qiu, Zhidong
[J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
[6] RESISTANCE OF BACTERIA TO ANTIBIOTICS
不详
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1955, 253 (23): : 1040 - 1042
[7] The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms
Van Goethem, Marc W.
Marasco, Ramona
Hong, Pei-Ying
Daffonchio, Daniele
[J]. MICROBIAL BIOTECHNOLOGY, 2024, 17 (03):
[8] Targeting Antibiotic Resistance: From Diagnostics to Novel Antibiotics
Li, Jian
Sexton, Patrick M.
[J]. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2020, 3 (03) : 371 - 372
[9] Antibiotic-Resistant Bacteria and the Use of Novel Antibiotics in Children
Lai, Evelyn
Bender, Jeffrey M.
[J]. PEDIATRIC ANNALS, 2018, 47 (09): : E354 - E358
[10] STUDIES ON ANTIBIOTIC SYNERGISM AND ANTAGONISM - THE EFFECT INVITRO OF COMBINATIONS OF ANTIBIOTICS ON BACTERIA OF VARYING RESISTANCE TO SINGLE ANTIBIOTICS
GUNNISON, JB
SHEVKY, MC
BRUFF, JA
COLEMAN, VR
JAWETZ, E
[J]. JOURNAL OF BACTERIOLOGY, 1953, 66 (02) : 150 - 158

← 1 2 3 4 5 →