Highly diastereoselective Michael addition of α-hydroxy acid derivatives and enantioselective synthesis of (+)-crobarbatic acid

被引：24
|
作者：
Jang, DP [1 ]
Chang, JW [1 ]
Uang, BJ [1 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 07期
关键词：
D O I：
10.1021/ol0069507
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Michael addition of enolates of 2a and 2b to alpha, beta -unsaturated esters took place selectively on different faces (Si and Re, respectively) of the double bond to give the corresponding products 4 and 5, respectively, with >98% de. Subsequent hydrolysis of these Micheal adducts gives 3,4-disubstituted gamma -lactones with high enantiomeric excesses.
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收藏
页码：983 / 985
页数：3
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