The prognostic impact of KRAS, TP53, STK11 and KEAP1 mutations and the influence of the NLR in NSCLC patients treated with immunotherapy.

被引：5
|
作者：
Proulx-Rocray, Francis
Routy, Bertrand
Nassabein, Rami Mohamad
El Ouarzadi, Omar
Belkaid, Wiam
Tran-Thanh, Danh
Florescu, Marie
Tehfe, Mustapha
Blais, Normand
机构：
[1] CHUM, Montreal, PQ, Canada
[2] Univ Montreal Res Ctr CRCHUM, Montreal, PQ, Canada
[3] Ctr Hosp Univ Montreal CHUM Notre Dame, Montreal, PQ, Canada
[4] Univ Montreal, Montreal, PQ, Canada
[5] Ctr Hosp Univ Montreal, Montreal, PQ, Canada
[6] Ctr Hosp Univ Montreal CHUM, Montreal, PQ, Canada
[7] Univ Montreal Hlth Ctr CHUM, Hematol Oncol Div, Montreal, PQ, Canada
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2021年 / 39卷 / 15期
关键词：
D O I：
10.1200/JCO.2021.39.15_suppl.e21010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
e21010
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Probing Mutant KRAS, STK11, KEAP1 in NSCLC
    Poh, Alissa
    [J]. CANCER DISCOVERY, 2022, 12 (10) : 2226 - 2226
  • [2] STK11 mutations predict poor prognosis for advanced NSCLC treated with first-line immunotherapy or chemoimmunotherapy according to KRAS, TP53, KEAP1, and SMARCA4 status
    De Giglio, A.
    de Biase, D.
    Di Federico, A.
    Maloberti, T.
    Casadio, C.
    Gruppioni, E.
    Altimari, A.
    Melotti, B.
    Sperandi, F.
    Gelsomino, F.
    Ardizzoni, A.
    [J]. ANNALS OF ONCOLOGY, 2023, 34
  • [3] Frequency and Prognostic Impact of Concomitant Mutations in KRAS and TP53 or STK11 in Brazilian Lung Adenocarcinoma Patients
    De Sa, V.
    Chinoca, J.
    Spina Donadio, M.
    De Lima, V.
    Torrezan, G.
    Carraro, D.
    Freitas, H.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (10) : S532 - S532
  • [4] Effects of KRAS, STK11, KEAP1, and TP53 mutations on the clinical outcomes of immune checkpoint inhibitors among patients with lung adenocarcinoma
    Liang, Yao
    Maeda, Osamu
    Kondo, Chiaki
    Nishida, Kazuki
    Ando, Yuichi
    [J]. PLOS ONE, 2024, 19 (07):
  • [5] Impact of STK11 Co-Mutation on Outcomes Following Immunotherapy Among Patients with TP53 and KRAS Mutated Stage IV NSCLC
    Marmarelis, M.
    Bange, E.
    Bagley, S.
    Hwang, W.
    Yang, Y.
    Thompson, J.
    Bauml, J.
    Ciunci, C.
    Alley, E.
    Morrissette, J.
    Cohen, R.
    Langer, C.
    Carpenter, E.
    Aggarwal, C.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (10) : S486 - S486
  • [6] Impact on KRAS-subtypes and TP53 mutations on the prognostic value of KRAS/KEAP1 comutations in non-small cell lung cancer (NSCLC)
    Scheffler, M.
    Frank, R.
    Ihle, M. A.
    Abdulla, D. S.
    Koleczko, S.
    Nogova, L.
    Holzem, A.
    Chanra, T.
    Riedel, R.
    Michels, S.
    Fischer, R. N.
    Kron, A.
    Merkelbach-Bruse, S.
    Buettner, R.
    Wolf, J.
    [J]. ANNALS OF ONCOLOGY, 2019, 30 : 55 - 55
  • [7] Impact of concomitant KRAS/STK11 or KRAS/KEAP1 mutations on response to immune checkpoint inhibition in NSCLC: A real-world data analysis
    Hempel, L. C.
    de Oliveira, J. Veloso
    Robert, S.
    Hempel, D.
    [J]. ANNALS OF ONCOLOGY, 2023, 34
  • [8] The Efficacy of Immunotherapy and Chemoimmunotherapy in STK11, KEAP1 & KRAS Gene Mutations in Advanced Non-small Cell Lung Cancer (NSCLC)
    Cheung, T. W.
    Morales, J.
    Sacks, H.
    Rolfo, C.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (11) : S630 - S630
  • [9] TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations
    Frille, Armin
    Boeschen, Myriam
    Wirtz, Hubert
    Stiller, Mathias
    Blaeker, Hendrik
    von Laffert, Maximilian
    [J]. FRONTIERS IN ONCOLOGY, 2024, 14
  • [10] Association of KRAS/STK11/ KEAP1 Mutations and Outcome in the POSEIDON Study: Durvalumab +/- Tremelimumab
    Reinmuth, N.
    Peters, S.
    Cho, B.
    Luft, A.
    Alatorre-Alexander, J.
    Geater, S.
    Kim, S.
    Ursol, G.
    Hussein, M.
    Lim, F.
    Yang, C.
    Araujo, L.
    Saito, H.
    Stewart, R.
    Lai, Z.
    Doake, R.
    Krug, L.
    Garon, E.
    Mok, T.
    Johnson, M.
    Eberhardt, W.
    [J]. PNEUMOLOGIE, 2023, 77 : S6 - S6
12345