IL-18 polymorphisms contribute to hepatitis B virus-related cirrhosis and hepatocellular carcinoma susceptibility in Chinese population: a case-control study

被引:18
|
作者
Dai, Zhi-Jun [1 ]
Liu, Xing-Han [1 ]
Wang, Meng [1 ]
Guo, Yan [2 ]
Zhu, Wenge [3 ]
Li, Xiao [4 ]
Lin, Shuai [1 ]
Tian, Tian [1 ]
Liu, Kang [1 ]
Zheng, Yi [1 ]
Xu, Peng [1 ]
Jin, Tianbo [5 ]
Li, Xiaopeng [6 ]
机构
[1] Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
[3] George Washington Univ, Sch Med, Dept Biochem & Mol Med, Washington, DC USA
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary Surg, Xian, Shaanxi, Peoples R China
[5] Northwest Univ Xian, Sch Life Sci, Natl Engn Res Ctr Miniaturized Detect Syst, Xian, Shaanxi, Peoples R China
[6] Xi An Jiao Tong Univ, Dept Ultrasound, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China
基金
中国博士后科学基金;
关键词
IL-18; HBV; susceptibility; INTERLEUKIN-18 PROMOTER POLYMORPHISMS; HAN POPULATION; ALCOHOL-CONSUMPTION; TH2; RESPONSES; BREAST-CANCER; LIVER-DISEASE; GENE PROMOTER; IFN-GAMMA; T-CELLS; ASSOCIATION;
D O I
10.18632/oncotarget.18531
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
IL-18 polymorphisms influence the transcriptional activity of the IL-18 gene and associated with various diseases. However, their relationships with hepatitis B virus-related liver diseases had not reached a consensus. So we conducted this case-control study with a view to clarifying the association. We included four groups: healthy controls, chronic hepatitis B virus (CHB) carriers, liver cirrhosis (LC) and hepatocellular carcinoma (HCC) groups with each group of 250 persons. Odd ratios (ORs) and 95% confidence intervals (95% CIs) with or without adjustment were calculated. Haplotype analysis was also performed. The results showed people carrying rs187238 CG genotype had a lower risk of LC (CG vs. CC: OR = 0.59, 95% CI = 0.38-0.91, P = 0.02), while GG genotype carriers had a higher risk of HCC (GG vs. CC+ CG: OR = 4.73, 95% CI = 1.01-22.1, P = 0.03) than those with CC and CG genotypes in healthy group. Rs187238 GG genotype increased the risk from CHB to LC status (GG vs. CC: OR = 4.81, 95% CI = 1.03-22.6; GG vs. CC+CG: OR = 4.73, 95% CI = 1.01-22.1), meanwhile the trend also existed by controlling confounding factors (GG vs. CC: OR = 6.25, 95% CI = 1.09-35.8; GG vs. CC+ CG: OR = 5.91, 95% CI = 1.04-33.7). Haplotype Crs187238Trs1946518 moderately decreased the risk of CHB carriers developing into HCC (OR = 0.69, 95% CI = 0.50-0.96, P = 0.03) after adjustment. In conclusion, IL-18 rs187238 GG genotype may increase the risk of HCC in healthy population and the risk of LC in CHB carriers.
引用
收藏
页码:81350 / 81360
页数:11
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