S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics

被引：2
|
作者：
Tsikas, Dimitrios [1 ]
Hanff, Erik [1 ]
Bollenbach, Alexander [1 ]
机构：
[1] Hannover Med Sch, Core Unit Prote, D-30623 Hannover, Germany
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2017年 / 23卷 / 40期
关键词：
S-Adenosyl-L-methionine; Bioavailability; Concentration; Liver; PLASMA HOMOCYSTEINE; MASS-SPECTROMETRY; ADENOSYLMETHIONINE; ADENOSYLHOMOCYSTEINE; METHYLATION; DISEASE; ERYTHROCYTES; GLUTATHIONE; METABOLISM; CELLS;
D O I：
10.3748/wjg.v23.i40.7343
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus -expressing cells at millimolar concentrations. The efficacy of SAM at micromolar concentrations and the underlying mechanisms remain to be demonstrated.
引用
收藏
页码：7343 / 7346
页数：4
相关论文
共 50 条
  • [1] S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics
    Dimitrios Tsikas
    Erik Hanff
    Alexander Bollenbach
    [J]. World Journal of Gastroenterology, 2017, (40) : 7343 - 7346
  • [2] S-ADENOSYL-L-METHIONINE IN A NEUROBLASTOMA
    LYON, GM
    [J]. PEDIATRIC RESEARCH, 1970, 4 (05) : 454 - &
  • [3] NEUROPHARMACOLOGY OF S-ADENOSYL-L-METHIONINE
    BALDESSARINI, RJ
    [J]. AMERICAN JOURNAL OF MEDICINE, 1987, 83 (5A): : 95 - 103
  • [4] S-ADENOSYL-L-METHIONINE AND THE LIVER
    ORTIZ, P
    MORENO, J
    PUERTA, JL
    MATO, JM
    [J]. ITALIAN JOURNAL OF GASTROENTEROLOGY, 1993, 25 (03): : 135 - 137
  • [5] Towards lipophilic derivatives of S-adenosyl-L-methionine
    Juanes, O
    Goya, P
    Martinez, A
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1998, 35 (03) : 727 - 730
  • [6] ERYTHROPOIETIC PROTOPORPHYRIA AND S-ADENOSYL-L-METHIONINE
    BATLLE, A
    STELLA, AM
    MELITO, V
    GOMEZ, HL
    PIETROPAOLO, N
    CABRERA, H
    PIERINI, A
    [J]. MOLECULAR ASPECTS OF MEDICINE, 1990, 11 (1-2) : 89 - 89
  • [7] ORAL S-ADENOSYL-L-METHIONINE IN DEPRESSION
    DEVANNA, M
    RIGAMONTI, R
    [J]. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1992, 52 (03): : 478 - 485
  • [8] PHARMACOKINETICS OF S-ADENOSYL-L-METHIONINE IN HEALTHY-VOLUNTEERS
    GIULIDORI, P
    CORTELLARO, M
    MOREO, G
    STRAMENTINOLI, G
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 27 (01) : 119 - 121
  • [9] INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE
    ABDELMONEM, MM
    PANKASKIE, MC
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 179 (MAR): : 55 - MEDI
  • [10] ENZYMATIC DECOMPOSITION OF S-ADENOSYL-L-METHIONINE
    SHAPIRO, SK
    MATHER, AN
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1958, 233 (03) : 631 - 633
12345