Caspofungin Etest Susceptibility Testing of Candida Species: Risk of Misclassification of Susceptible Isolates of C. glabrata and C-krusei when Adopting the Revised CLSI Caspofungin Breakpoints

被引：55

作者：

Arendrup, Maiken Cavling ^{[1
]}

Pfaller, Michael A. ^{[2
,3
]}

机构：

[1] Statens Serum Inst, Unit Mycol, Dept Microbiol Surveillance & Res, DK-2300 Copenhagen, Denmark

[2] JMI Labs, Iowa City, IA USA

[3] Univ Iowa, Iowa City, IA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 07期

关键词：

INVASIVE CANDIDIASIS; ALBICANS; MICAFUNGIN; ANIDULAFUNGIN; ECHINOCANDINS;

D O I：

10.1128/AAC.00355-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The purpose of this study was to evaluate the performance of caspofungin Etest and the recently revised CLSI breakpoints. A total of 497 blood isolates, of which 496 were wild-type isolates, were included. A total of 65/496 susceptible isolates (13.1%) were misclassified as intermediate (I) or resistant (R). Such misclassifications were most commonly observed for Candida krusei (73.1%) and Candida glabrata (33.1%). The revised breakpoints cannot be safely adopted for these two species.

引用

页码：3965 / 3968

页数：4

共 4 条

[1] Should echinocandin doses be increased against Candida species? An in vitro and in vivo study of caspofungin against Candida albicans, C. krusei and C. inconspicua
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Berenyi, R.
Doman, M.
Kardos, G.
Juhasz, B.
Majoros, L.
MYCOSES, 2013, 56 : 60 - 60
[2] Differences in Killing Activity of Caspofungin and Paradoxical Growth Between Candida albicans and C. krusei Clinical Isolates in Different Media
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Soczo, G.
Kardos, G.
Kemeny-Beke, A.
Kelentey, B.
Marton, I.
Majoros, L.
JOURNAL OF CHEMOTHERAPY, 2009, 21 (01) : 36 - 41
[3] Mutations in the fks1 gene in Candida albicans, C-tropicalis, and C-krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing
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Raoux, Dorothee
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (09) : 3092 - 3098
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Melhem, Marcia S. C.
Coelho, Vivian C.
Fonseca, Claudia A.
de Oliveira, Lidiane
Bonfietti, Lucas X.
Szeszs, Maria W.
Magri, Marcello M. C.
Dorneles, Francine S.
Taguchi, Hideaki
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Motta, Adriana L.
Batista, Marjorie, V
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PHARMACEUTICS, 2022, 14 (10)

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