SUSTAINED DELIVERY OF IL-1RA FROM PLGA MICROSPHERES ATTENUATES IL-1β MEDIATED INFLAMMATION IN A CARTILAGE TISSUE ANALOG

被引:0
|
作者
Gorth, D. J. [1 ]
Strutz, W. [1 ]
Mohanraj, B. [1 ]
Mauck, R. L. [1 ]
Smith, L. J. [1 ]
Dodge, G. R. [1 ]
机构
[1] Univ Penn, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/j.joca.2012.02.150
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
引用
收藏
页码:S121 / S121
页数:1
相关论文
共 50 条
  • [1] The role of IL-1 and IL-1RA in joint inflammation and cartilage degradation
    Jacques, Claire
    Gosset, Marjolaine
    Berenbaum, Francis
    Gabay, Cem
    [J]. INTERLEUKINS, 2006, 74 : 371 - 403
  • [2] IL-1 receptor antagonist (IL-1Ra) plasma levels are coordinately regulated by both IL-1Ra and IL-1β genes
    Hurme, M
    Santtila, S
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1998, 28 (08) : 2598 - 2602
  • [3] IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro
    Deborah J Gorth
    Robert L Mauck
    Joseph A Chiaro
    Bhavana Mohanraj
    Nader M Hebela
    George R Dodge
    Dawn M Elliott
    Lachlan J Smith
    [J]. Arthritis Research & Therapy, 14
  • [4] IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro
    Gorth, Deborah J.
    Mauck, Robert L.
    Chiaro, Joseph A.
    Mohanraj, Bhavana
    Hebela, Nader M.
    Dodge, George R.
    Elliott, Dawn M.
    Smith, Lachlan J.
    [J]. ARTHRITIS RESEARCH & THERAPY, 2012, 14 (04)
  • [5] IL-1β and IL-1ra;: Their interaction and modulation of inflammation in asthmatic airways.
    Lustine, HT
    Zangrilli, JG
    Hastie, AT
    Reinach, AJ
    Colavita, AM
    Pollice, M
    Fish, JE
    Peters, SP
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) : A21 - A21
  • [6] The IL-1 and IL-1 receptor antagonist (IL-1Ra) response of human neutrophils to EBV stimulation - Preponderance of IL-1Ra detection
    Roberge, CJ
    Poubelle, PE
    Beaulieu, AD
    Heitz, D
    Gosselin, J
    [J]. JOURNAL OF IMMUNOLOGY, 1996, 156 (12): : 4884 - 4891
  • [7] The balance between IL-1 and IL-1Ra in disease
    Arend, WR
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (4-5) : 323 - 340
  • [8] 脑卒中患者血清IL-1β、IL-1Ra、IL-1Ra/IL-1β比值的监测及临床意义
    唐任光
    韦叶生
    龙显科
    [J]. 陕西医学杂志, 2005, (04) : 400 - 402
  • [9] Sustained release of IL-1Ra from biodegradable microspheres prolongs its IL-1-neutralizing effects
    Lavi, G
    Dinarello, CA
    Apte, RN
    Cohen, S
    [J]. ISRAEL JOURNAL OF CHEMISTRY, 2005, 45 (04) : 457 - 464
  • [10] IN VIVO DELIVERY OF IL-1RA FROM PLGA MICROSPHERES PREVENTS IL-1B INDUCED GLYCOSAMINOGLYCAN LOSS IN THE RAT CAUDAL INTERVERTEBRAL DISC
    Gorth, Deborah J.
    Martin, John T.
    Dodge, George R.
    Hebela, Nader M.
    Malhotra, Neil R.
    Mauck, Robert L.
    Elliott, Dawn M.
    Smith, Lachlan J.
    [J]. PROCEEDINGS OF THE ASME 2ND GLOBAL CONGRESS ON NANOENGINEERING FOR MEDICINE AND BIOLOGY, NEMB 2013, 2013, : 53 - 54