Subcellular localization of IRS-1 in cell proliferation and differentiation

被引：0
|
作者：
Tu, X [1 ]
Wu, A [1 ]
Maiorana, A [1 ]
Baserga, R [1 ]
机构：
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
来源：
HORMONE AND METABOLIC RESEARCH | 2003年 / 35卷 / 11-12期
关键词：
IGF-I receptor; nuclear IRS-1; differentiation;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1), play important roles in cell transformation, cell differentiation and aging. IRS-1 and other IRS proteins can, under certain conditions, localize to the nuclei of cells, where they undergo interactions with nuclear and nucleolar proteins. In this study, we confirm and extend these observations, demonstrating that IRS-1 is preferentially nuclear in growing cells. Differentiation and inhibition of ribosomal RNA synthesis cause subcellular redistribution of IRS-1 and other nuclear proteins to the cytoplasm.
引用
收藏
页码：734 / 739
页数：6
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