Hepatoprotection via the IL-6/Stat3 pathway

被引：191
|
作者：
Taub, R [1 ]
机构：
[1] Bristol Myers Squibb Co, Wallingford, CT 06492 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期
关键词：
D O I：
10.1172/JCI20031200319974
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study (see the related article beginning on page 989) demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.
引用
收藏
页码：978 / 980
页数：3
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