Distribution of endothelin-1-like activity in the cochlea of normal guinea pigs

被引：13
|
作者：
Jinnouchi, K
Tomiyama, S
Pawankar, R
Ikezono, T
Yagi, T
机构：
[1] Department of Otolaryngology, Nippon Medical School, Tokyo
[2] Department of Otolaryngology, Nippon Medical School, Bunkyo, Tokyo, 113
来源：
ACTA OTO-LARYNGOLOGICA | 1997年 / 117卷 / 01期
关键词：
immunohistochemistry; endothelin-1; cochlea; guinea pig;
D O I：
10.3109/00016489709117989
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Distribution of endothelin-1 (ET-1) in the cochlea of normal guinea pigs was determined by immunohistochemistry. ET-1 activity was identified with the mouse anti-human ET-1 IgG1 monoclonal antibody. ET-1 activity was distributed in the modiolus, spiral ligament, stria vascularis, spiral prominence, Reissner's membrane, supporting cells of the organ of Corti and spiral ganglion cells. These findings suggest that ET-1 may be involved in the regulation of fluid volume and ions of the cochlea.
引用
收藏
页码：41 / 45
页数：5
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