Fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus

被引：7

作者：

Beunen, Kaat ^{[1
]}

Neys, Astrid ^{[2
]}

Van Crombrugge, Paul ^{[3
]}

Moyson, Carolien ^{[1
]}

Verhaeghe, Johan ^{[4
]}

Vandeginste, Sofie ^{[5
]}

Verlaenen, Hilde ^{[5
]}

Vercammen, Chris ^{[6
]}

Maes, Toon ^{[6
]}

Dufraimont, Els ^{[7
]}

Roggen, Nele ^{[7
]}

De Block, Christophe ^{[8
]}

Jacquemyn, Yves ^{[9
]}

Mekahli, Farah ^{[10
]}

De Clippel, Katrien ^{[11
]}

van den Bruel, Annick ^{[12
]}

Loccufier, Anne ^{[13
]}

Laenen, Annouschka ^{[14
]}

Devlieger, Roland ^{[4
]}

Mathieu, Chantal ^{[1
]}

Benhalima, Katrien ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Endocrinol, Univ Hosp Gasthuisberg, Herestr 49, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Herestr 49, B-3000 Leuven, Belgium

[3] OLV Ziekenhuis Aalst Asse Ninove, Dept Endocrinol, Moorselbaan 164, B-9300 Aalst, Belgium

[4] Katholieke Univ Leuven, Dept Obstet & Gynecol, Univ Hosp Gasthuisberg, Herestr 49, B-3000 Leuven, Belgium

[5] OLV Ziekenhuis Aalst Asse Ninove, Dept Obstet & Gynecol, Moorselbaan 164, B-9300 Aalst, Belgium

[6] Imelda Ziekenhuis, Dept Endocrinol, Imeldalaan 9, B-2820 Bonheiden, Belgium

[7] Imelda Ziekenhuis, Dept Obstet & Gynecol, Imeldalaan 9, B-2820 Bonheiden, Belgium

[8] Antwerp Univ Hosp, Dept Endocrinol Diabetol Metab, Drie Eikenstr 655, B-2650 Edegem, Belgium

[9] Antwerp Univ Hosp, Dept Obstet & Gynecol, Drie Eikenstr 655, B-2650 Edegem, Belgium

[10] Kliniek St Jan Brussel, Dept Endocrinol, Kruidtuinlaan 32, B-1000 Brussels, Belgium

[11] Kliniek St Jan Brussel, Dept Obstet & Gynecol, Kruidtuinlaan 32, B-1000 Brussels, Belgium

[12] AZ St Jan Brugge, Dept Endocrinol, Ruddershove 10, B-8000 Brugge, Belgium

[13] AZ St Jan Brugge, Dept Obstet & Gynecol, Ruddershove 10, B-8000 Brugge, Belgium

[14] Katholieke Univ Leuven, Ctr Biostat & Stat Bioinformat, Kapucijnenvoer 35 Bloc D,Box 7001, B-3000 Leuven, Belgium

来源：

ACTA DIABETOLOGICA | 2022年 / 59卷 / 03期

关键词：

Fasting plasma glucose; Screening; Gestational diabetes mellitus; Pregnancy outcomes; INTERNATIONAL ASSOCIATION; INSULIN SENSITIVITY; EUROPEAN BOARD; PREGNANCY; TOLERANCE; CRITERIA; RECOMMENDATIONS; HYPERGLYCEMIA; POPULATION; GYNECOLOGY;

D O I：

10.1007/s00592-021-01812-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims To determine the fasting plasma glucose (FPG) level at which an oral glucose tolerance test (OGTT) could be avoided to screen for gestational diabetes (GDM) and to evaluate the characteristics of women across this FPG threshold. Methods A multi-centric prospective cohort study with 1843 women receiving universal screening for GDM with a 75 g OGTT. Results In the total population, GDM prevalence was 12.5% (231). A FPG < 78 mg/dL was the cut-off with best trade-off to limit the number of missed GDM cases [44 (19.0%)] with a negative predictive value of 97.3% (95% CI 96.5-98.0) for GDM, while avoiding 52.2% OGTTs. Compared to GDM with FPG >= 78 mg/dL [187 (81.0%)], GDM women with FPG < 78 mg/dL had a significantly lower BMI (27.1 +/- 4.5 vs. 29.6 +/- 5.2 kg/m(2), p = 0.003), less insulin resistance [Matsuda: 0.4 (0.4-0.7) vs. 0.3 (0.2-0.5), p < 0.001] and better beta-cell function [ISSI-2: 0.13 (0.08-0.25) vs. 0.09 (0.04-0.15), p = 0.004]. Compared to NGT women (1612) with FPG >= 78 mg/dL [846 (52.5%)], NGT with FPG < 78 mg/dL [766 (47.5%)] had a significantly lower BMI (26.0 +/- 3.9 vs. 27.8 +/- 4.7 kg/m(2), p < 0.001), less insulin resistance [Matsuda: 0.7 (0.5-0.9) vs. 0.5 (0.4-0.7), p < 0.001], better beta-cell function [ISSI-2: 0.17 (0.10-0.30) vs. 0.12 (0.07-0.21), p < 0.001], and less often large-for-gestational age infants [9.2 (70) vs. 16.2% (136), p < 0.001]. Conclusions FPG < 78 mg/dL can be used to limit the number of OGTTs when screening for GDM. Women with FPG < 78 mg/dL had a better metabolic profile and in NGT women also less fetal overgrowth.

引用

页码：381 / 394

页数：14

共 50 条

[1] Fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus
Kaat Beunen
Astrid Neys
Paul Van Crombrugge
Carolien Moyson
Johan Verhaeghe
Sofie Vandeginste
Hilde Verlaenen
Chris Vercammen
Toon Maes
Els Dufraimont
Nele Roggen
Christophe De Block
Yves Jacquemyn
Farah Mekahli
Katrien De Clippel
Annick Van Den Bruel
Anne Loccufier
Annouschka Laenen
Roland Devlieger
Chantal Mathieu
Katrien Benhalima
[J]. Acta Diabetologica, 2022, 59 : 381 - 394
[2] Response to "Fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus"
Llerena-Velastegui, Jordan
Guevara-Espinoza, Sofia
Villacis-Lopez, Cecibel
Santafe-Abril, Gerson
[J]. ACTA DIABETOLOGICA, 2023, 60 (06) : 857 - 858
[3] Response to “Fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus”
Jordan Llerena-Velastegui
Sofia Guevara-Espinoza
Cecibel Villacis-Lopez
Gerson Santafe-Abril
[J]. Acta Diabetologica, 2023, 60 : 857 - 858
[4] Reply to letter to the editor (response to "fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus")
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Benhalima, Katrien
[J]. ACTA DIABETOLOGICA, 2023, 60 (06) : 859 - 860
[5] Reply to letter to the editor (response to "fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus")
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Katrien Benhalima
[J]. Acta Diabetologica, 2023, 60 (6) : 859 - 860
[6] Fasting plasma glucose to avoid a full OGTT in the diagnosis of gestational diabetes
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[J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 105 (03) : 322 - 326
[7] Gestational diabetes mellitus: Screening with fasting plasma glucose
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[J]. WORLD JOURNAL OF DIABETES, 2016, 7 (14) : 279 - 289
[8] Fasting Glucose Level on the Oral Glucose Tolerance Test Is Associated with the Need for Pharmacotherapy in Gestational Diabetes Mellitus
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[J]. NUTRIENTS, 2023, 15 (05)
[9] Fasting plasma glucose as a screening test for gestational diabetes mellitus
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[J]. Archives of Gynecology and Obstetrics, 2007, 275 (2) : 81 - 87
[10] The role of fasting plasma glucose in the diagnosis of gestational diabetes mellitus
Osar, Z
Madazli, R
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Ilkova, H
[J]. DIABETOLOGIA, 2002, 45 : A286 - A287

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