Cytotoxic activities of Solanum steroidal glycosides

被引：0
|
作者：
Nakamura, T
Komori, C
Lee, YY
Hashimoto, F
Yahara, S
Nohara, T
Ejima, A
机构：
[1] KUMAMOTO UNIV, FAC PHARMACEUT SCI, KUMAMOTO 862, JAPAN
[2] DAIICHI PHARMACEUT CO LTD, EXPLORATORY RES LABS 1, EDOGAWA KU, TOKYO 134, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1996年 / 19卷 / 04期
关键词：
cytotoxic activity; Solanum alkaloid; steroidal glycoside; beta-chacotriosyl moiety;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytotoxic activities of 20 steroidal glycosides obtained from Solanum genera plants were examined against various cell lines to provide new evidence as follows: 1) As regarding the sugar linkage, the glycosides possessing a beta-chacotriosyl moiety were the most effective and the presence of the terminal rhamnosyl residue was required for exhibiting strong activity, 2) As for the aglycone, the glycosides carrying a spirostanol aglycone showed the strongest activity and even an aglycone without a sugar linkage presented considerably strong activity.
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页码：564 / 566
页数：3
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