Cancer metabolism: facts, fantasy, and fiction

被引：473
|
作者：
Zu, XL [1 ]
Guppy, M [1 ]
机构：
[1] Univ Western Australia, Sch Biochem & Chem Sci, Crawley, WA 6009, Australia
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 313卷 / 03期
关键词：
D O I：
10.1016/j.bbrc.2003.11.136
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data from the last 40 years on this issue. We conclude that there is no evidence that cancer cells are inherently glycolytic, but that some tumours might indeed be glycolytic in vivo as a result of their hypoxic environment. (C) 2003 Elsevier Inc. All rights reserved.
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页码：459 / 465
页数：7
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