Attention-Deficit/Hyperactivity Disorder, Its Pharmacotherapy, and Adrenal Gland Dysfunction: A Nationwide Population-Based Study in Taiwan

被引:1
|
作者
Peng, Pin-Han [1 ,2 ]
Tsai, Meng-Yun [3 ]
Lee, Sheng-Yu [2 ,4 ,5 ]
Liao, Po-Cheng [6 ]
Shyu, Yu-Chiau [6 ,7 ,8 ]
Wang, Liang-Jen [2 ,9 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung 833, Taiwan
[2] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan
[3] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung 833, Taiwan
[4] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung 813, Taiwan
[5] Kaohsiung Med Univ, Grad Inst Med, Dept Psychiat, Coll Med,Sch Med, Kaohsiung 807, Taiwan
[6] Keelung Chang Gung Mem Hosp, Community Med Res Ctr, Keelung 204, Taiwan
[7] Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan
[8] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan
[9] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung 833, Taiwan
关键词
ADHD; comorbidity; adrenal gland dysfunction; epidemiology; pharmacotherapy; SALIVARY CORTISOL; CHILDREN; STRESS; METHYLPHENIDATE; PROFILES; ATOMOXETINE; INHIBITION; DIAGNOSIS;
D O I
10.3390/ijerph17103709
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This study aims to examine the co-occurrence rate of attention deficit hyperactivity disorder (ADHD) and adrenal gland disorders, as well as whether pharmacotherapy may affect ADHD patients' risk of developing adrenal gland disorder. One group of patients newly diagnosed with ADHD (n = 75,247) and one group of age- and gender-matching controls (n = 75,247) were chosen from Taiwan ' s National Health Insurance database during the period of January 1999 to December 2011. Both patients and controls were monitored through December 31, 2011, in order to identify the occurrence of adrenal gland disorders (ICD-9-CM code 255.X). We also explored the potential effect of methylphenidate (MPH) and atomoxetine (ATX) treatments on the risk of developing adrenal gland disorders. We found that ADHD patients showed a significantly increased probability of developing an adrenal gland disorder compared to the control group (0.2% of ADHD vs. 0.1% of controls). However, neither MPH nor ATX treatment significantly influenced the patients' risk of developing adrenal gland dysfunction. We propose that patients with ADHD had greater comorbid rates with adrenal gland dysfunction than the control subjects. Nevertheless, undergoing treatment with MPH or ATX did not significantly influence the risk of developing adrenal gland dysfunction among ADHD patients.
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页数:10
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