Synthesis and structure-activity relationship of novel 4-substituted pyrazolo[1,5-a]pyridine analogs as potent MAPKAP-K2 inhibitors

被引：0
|
作者：
Unoki, Gen [1 ]
Matsumoto, Yoshiyuki [1 ]
Matsueda, Yohei [1 ]
Hamada, Motoko [1 ]
Kosugi, Tomomi [1 ]
Kambe, Mika [1 ]
Shimada, Tomohiro [1 ]
Imai, Minoru [1 ]
Makino, Hiroaki [1 ]
Yamakoshi, Yuko [1 ]
Takenouchi, Osami [1 ]
Oue, Yasuhiro [1 ]
Fujino, Aiko [1 ]
Takimoto-Kamimura, Midori [1 ]
Kataoka, Ken-ichiro [1 ]
机构：
[1] Teijin Pharma Ltd, Teijin Inst Biomed Res, Tokyo, Japan
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 241卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
259-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Synthesis and structure-activity relationship of novel 4-substituted pyrazolo[1,5-a]pyridine analogs as potent MAPKAP-K2 inhibitors
    Unoki, Gen
    Matsumoto, Yoshiyuki
    Matsueda, Yohei
    Hamada, Motoko
    Kosugi, Tomomi
    Kambe, Mika
    Shimada, Tomohiro
    Imai, Minoru
    Makino, Hiroaki
    Yamakoshi, Yuko
    Takenouchi, Osami
    Oue, Yasuhiro
    Sakai, Yuri
    Fujino, Aido
    Takimoto-Kamimura, Midori
    Kataoka, Ken-ichiro
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [2] Discovery of Pyrazolo[1,5-a]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors
    Wang, Chun
    Zou, Fengming
    Qi, Ziping
    Liu, Qingwang
    Shen, Lijuan
    Yuan, Xinyu
    Deng, Maoqing
    Wang, Aoli
    Wang, Beilei
    Wang, Li
    Liang, Xiaofei
    Liu, Qingsong
    Liu, Jing
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (17) : 15199 - 15219
  • [3] Synthesis and Structure-Activity Relationships of Pyrazolo[1,5-a]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor
    Takahashi, Yoshinori
    Hibi, Shigeki
    Hoshino, Yorihisa
    Kikuchi, Koichi
    Shin, Kogyoku
    Murata-Tai, Kaoru
    Fujisawa, Masae
    Ino, Mitsuhiro
    Shibata, Hisashi
    Yonaga, Masahiro
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) : 5255 - 5269
  • [4] Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
    Chen, Yun
    Bai, Gang
    Li, Yan
    Ning, Yi
    Cao, Sufen
    Zhou, Jinpei
    Ding, Jian
    Zhang, Huibin
    Xie, Hua
    Duan, Wenhu
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 48
  • [5] Discovery of novel pyrazolo[1,5-a]pyridine-based EP1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships
    Nishigaya, Yosuke
    Umei, Kentaro
    Saito, Yoshifumi
    Watanabe, Hiroyuki
    Kondo, Tatsuhiro
    Kondo, Atsushi
    Kawamura, Naohiro
    Tatani, Kazuya
    Kohno, Yasushi
    Tanaka, Nobuyuki
    Seto, Shigeki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (17) : 4044 - 4050
  • [6] Novel pyrazolo[1,5-a]pyridines as orally active EP1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation
    Umei, Kentaro
    Nishigaya, Yosuke
    Kondo, Atsushi
    Tatani, Kazuya
    Tanaka, Nobuyuki
    Kohno, Yasushi
    Seto, Shigeki
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (09) : 2635 - 2642
  • [7] Novel and Efficient Synthesis of 7-Trifluoromethyl-Substituted Pyrazolo[1,5-a] Pyrimidines with Potent Antitumor Agents
    Mulakayala, Naveen
    Reddy, Upendar C. H.
    Chaitanya, M.
    Hussain, Manzoor Md
    Kumar, Chitta Suresh
    Golla, Narayanaswamy
    JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2011, 55 (04): : 719 - 722
  • [8] Pyrazolo-[1,5-a]-1,3,5-triazine CRF receptor antagonists: Synthesis and structure-activity relationships of 8-(substituted phenyl) analogs.
    Gilligan, PJ
    He, LQ
    Clarke, T
    Fitzgerald, L
    McElroy, J
    Grossman, S
    Arneric, S
    Tivitmahaisoon, P
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U558 - U558
  • [9] Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines
    Huo, Xian-Sen
    Jian, Xie-Er
    Ou-Yang, Jie
    Chen, Lin
    Yang, Fang
    Lv, Dong-Xin
    You, Wen-Wei
    Rao, Jin-Jun
    Zhao, Pei-Liang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 220
  • [10] SYNTHESIS OF 3-SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON PLATELET-AGGREGATION .1.
    AWANO, K
    SUZUE, S
    SEGAWA, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (07) : 2828 - 2832
12345