Hippocampal mossy fiber LTP is independent of postsynaptic calcium

被引：87
|
作者：
Mellor, J
Nicoll, RA [1 ]
机构：
[1] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
来源：
NATURE NEUROSCIENCE | 2001年 / 4卷 / 02期
关键词：
D O I：
10.1038/83941
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We tested a proposal that postsynaptic calcium and metabotropic glutamate receptors (mGluRs) are involved in the induction of hippocampal mossy fiber long-term potentiation (LTP)1. We found that blockade of mGluRs with a range of antagonists, or dialysis of the postsynaptic cell with 50 mM BAPTA, had no effect on mossy fiber LTP. Therefore, we concluded that mossy fiber LTP is independent of postsynaptic calcium.
引用
收藏
页码：125 / 126
页数：2
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