Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

被引：166
|
作者：
Lynch, JR [1 ]
Morgan, D [1 ]
Mance, J [1 ]
Matthew, WD [1 ]
Laskowitz, DT [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med Neurol, Durham, NC 27710 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 114卷 / 1-2期
关键词：
apolipoprotein E; microglia; TNFa; IL-6; IL-1;
D O I：
10.1016/S0165-5728(00)00459-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNF alpha, Il-1 beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：107 / 113
页数：7
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