Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses

The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen, Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously tit = 6), horses given intravenous phenylbutazone tit = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6), The mean time to reach maximum serum acetaminophen concentration (T-max), the maximum serum concentration (C-max), and the area under the serum acetaminophen concentration versus time curve (AUC) mere compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.