Synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation

被引：403
|
作者：
Groebke, K [1 ]
Weber, L [1 ]
Mehlin, F [1 ]
机构：
[1] Hoffmann La Roche Ag, Preclin Res, Div Pharma, CH-4070 Basel, Switzerland
来源：
SYNLETT | 1998年 / 06期
关键词：
combinatorial chemistry; multicomponent condensation; Ugi reaction; heterobicyclic compounds; imidazopyridines; imidazopyrazines; imidazopyrimidines;
D O I：
10.1055/s-1998-1721
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel three-component, one-pot condensation yielding 3-amino-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines and imidazo[1,2-a]pyrimidines from aldehydes, isonitriles and 2-amino-pyridine, 2-amino-pyrazine or 2-amino-pyrimidine is described.
引用
收藏
页码：661 / +
页数：4
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