Hydrophilic interaction chromatography in drug analysis

被引：21
|
作者：
Ares, Ana M. [1 ]
Bernal, Jose [1 ]
机构：
[1] Univ Valladolid, Analyt Chem Grp, I U CINQUIMA, E-47071 Valladolid, Spain
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2012年 / 10卷 / 03期
关键词：
HILIC; Stationary phases; Detectors; Drug Analysis; TANDEM MASS-SPECTROMETRY; INTERACTION LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; STABILITY-INDICATING ASSAY; LIGHT-SCATTERING DETECTION; WASTE-WATER TREATMENT; HUMAN PLASMA; LC-MS/MS; QUANTITATIVE-DETERMINATION; RAT PLASMA;
D O I：
10.2478/s11532-012-0003-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrophilic interaction chromatography (HILIC) is an increasingly popular alternative to conventional HPLC for drug analysis. It offers increased selectivity and sensitivity, and improved efficiency when quantifying drugs and related compounds in complex matrices such as biological and environmental samples, pharmaceutical formulations, food, and animal feed. In this review we summarize HILIC methods recently developed for drug analysis (2006-2011). In addition, a list of important applications is provided, including experimental conditions and a brief summary of results. The references provide a comprehensive overview of current HILIC applications in drug analysis.
引用
收藏
页码：534 / 553
页数：20
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