PROGNOSTIC VALUE OF THE MONOCYTE/HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO IN DIABETIC NEPHROPATHY PATIENTS

Introduction: Diabetic nephropathy (DN), a microvascular complication associated with diabetes mellitus (DM), manifests in urinary albumin excretion (UAE) and may lead to end-stage renal failure. Recent studies have reported that the monocyte/ high-density lipoprotein cholesterol ratio (MHR) serves as an inflammatory marker. The purpose of this study is to analyze the prognostic value of the MHR in DN patients. Material and methods: The medical records of type 2 DM patients who received follow-up care at the internal medicine clinic were examined, and the data of all patients who had undergone estimation of 24-hour UAE were recorded. These patients were separated into 3 groups on the basis of the UAE levels and the biochemical data and the MHR were compared between the groups. Results: The serum creatinine (p = 0.008), 24-hour UAE (p < 0.001), and MHR (p = 0.005) were all significantly different between the groups. The MHR was positively correlated to the 24-hour UAE (p = 0.007) and negatively correlated to the glomerular filtration rate (GFR) (p = 0.023). Conclusion: The MHR can be an inexpensive, accessible, and useful early prognostic marker in diabetic nephropathy patients.