Improving human kidney function in renovascular disease with mesenchymal stem cell therapy

被引：8
|
作者：
Sivanathan, Kisha N. [1 ,2 ,3 ]
Coates, P. Toby [3 ,4 ]
机构：
[1] Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
[3] Univ Adelaide, Sch Med, Fac Hlth & Med Sci, Adelaide, SA, Australia
[4] Royal Adelaide Hosp, Cent Northern Adelaide Renal Transplantat Serv, Adelaide, SA, Australia
来源：
KIDNEY INTERNATIONAL | 2020年 / 97卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.kint.2019.12.020
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A dose escalation study of adipose-derived human mesenchymal stem cell (MSC) therapy was studied in 21 subjects. This dose escalation study confirmed no significant cellular toxicity, but it showed improvement in renal oxygenation and glomerular filtration rate. No significant renal toxicity from cell therapy was shown. A reduction in inflammatory markers including tumor necrosis factor-a, interferon-g, and neutrophil gelatinase-associated lipocalin was noted in subjects receiving MSC therapy. This study provides short-term safety and renal efficacy for MSC therapy and paves the way forward for future MSC-based interventions in renovascular disease.
引用
收藏
页码：655 / 656
页数：3
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