Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

被引：33
|
作者：
Mazurenka, M. [1 ]
Behrendt, L. [1 ]
Meinhardt-Wollweber, M. [1 ]
Morgner, U. [2 ]
Roth, B. [1 ]
机构：
[1] Leibniz Univ Hannover, Hannover Ctr Opt Technol HOT, Nienburger Str 17, D-30167 Hannover, Germany
[2] Leibniz Univ Hannover, Inst Quantenopt, Welfengarten 1, D-30167 Hannover, Germany
来源：
REVIEW OF SCIENTIFIC INSTRUMENTS | 2017年 / 88卷 / 10期
关键词：
OPTICAL COHERENCE TOMOGRAPHY; SPECTROSCOPY; TISSUE; DIAGNOSIS; FIBER; SYSTEM;
D O I：
10.1063/1.5004999
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening. Published by AIP Publishing.
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页数：6
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