Efficient silver-free gold(I)-catalyzed hydration of alkynes at low catalyst loading

被引：95

作者：

Nun, Pierrick ^{[1
]}

Ramon, Ruben S. ^{[1
]}

Gaillard, Sylvain ^{[1
]}

Nolan, Steven P. ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2011年 / 696卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Gold catalysis; Alkyne hydration; Acid activation; Ketones; GOLD(I) COMPLEXES; CYCLOISOMERIZATION; ACTIVATION; ACETALS; LIGAND;

D O I：

10.1016/j.jorganchem.2010.08.052

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The use of [(IPr)AuOH] as versatile, air- and moisture-stable pre-catalyst permits the in situ generation of the cationic gold(I) species [(IPr)Au]X after reaction with a Bronsted acid. This catalytic system presents as a main advantage the lack of use of a silver salt activator or co-catalyst which is often air-, light- and moisture-sensitive. A general gold(I)-catalyzed procedure using this in situ activation at very low catalyst loading is reported for the hydration of a broad range of internal and terminal alkynes. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：7 / 11

页数：5

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