Endocrine regulation of ageing

被引：263
|
作者：
Russell, Steven J.
Kahn, C. Ronald
机构：
[1] Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 09期
关键词：
D O I：
10.1038/nrm2234
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the past 15 years it has become clear that mutations in genes that regulate endocrine signalling pathways can prolong lifespan. Lifespan can be increased by altered endocrine signalling in a group of cells or a single tissue, which indicates that crosstalk between tissues functions to coordinate ageing of the organism. These endocrine pathways might serve as targets for the manipulation of the ageing process and prevention of age-related diseases.
引用
收藏
页码：681 / 691
页数：11
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