The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation

被引：27
|
作者：
Nguyen, John H. [1 ]
Chung, Jin D. [1 ]
Lynch, Gordon S. [1 ]
Ryall, James G. [1 ]
机构：
[1] Univ Melbourne, Ctr Muscle Res, Dept Physiol, Melbourne, Vic, Australia
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
injury; repair; skeletal muscle; metabolism; metabolic reprogramming; PENTOSE-PHOSPHATE PATHWAY; 1-PHOSPHATE STIMULATES PROLIFERATION; SKELETAL-MUSCLE; SATELLITE CELLS; CANCER-CELLS; TRIOSEPHOSPHATE ISOMERASE; METABOLIC REQUIREMENTS; GLUTAMINE-METABOLISM; SYNTHETASE-ACTIVITY; AEROBIC GLYCOLYSIS;
D O I：
10.3389/fcell.2019.00254
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Skeletal muscle has a remarkable capacity to regenerate following injury, a property conferred by a resident population of muscle stem cells (MuSCs). In response to injury, MuSCs must double their cellular content to divide, a process requiring significant new biomass in the form of nucleotides, phospholipids, and amino acids. This new biomass is derived from a series of intracellular metabolic cycles and alternative routing of carbon. In this review, we examine the link between metabolism and skeletal muscle regeneration with particular emphasis on the role of the cellular microenvironment in supporting the production of new biomass and MuSC proliferation.
引用
收藏
页数：12
相关论文
共 50 条
  • [1] Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment
    Line Verckist
    Isabel Pintelon
    Jean-Pierre Timmermans
    Inge Brouns
    Dirk Adriaensen
    Respiratory Research, 19
  • [2] Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment
    Verckist, Line
    Pintelon, Isabel
    Timmermans, Jean-Pierre
    Brouns, Inge
    Adriaensen, Dirk
    RESPIRATORY RESEARCH, 2018, 19
  • [3] Plasticity of the Muscle Stem Cell Microenvironment
    Dinulovic, Ivana
    Furrer, Regula
    Handschin, Christoph
    STEM CELL MICROENVIRONMENTS AND BEYOND, 2017, 1041 : 141 - 169
  • [4] A Sox Transcription Factor Is a Critical Regulator of Adult Stem Cell Proliferation in the Drosophila Intestine
    Meng, Fanju W.
    Biteau, Benoit
    CELL REPORTS, 2015, 13 (05): : 906 - 914
  • [5] Nucleophosmin, a critical regulator of cell proliferation, is overexpressed in prostate
    Nigwekar, P.
    Wu, C.
    Yao, J. L.
    Bourne, P. A.
    Li, J.
    Zhuang, Z.
    di Sant'Agnese, P. A.
    Walters, D. C.
    Huang, J.
    LABORATORY INVESTIGATION, 2007, 87 : 166A - 167A
  • [6] REGULATION OF LEUKEMIC STEM CELL PROLIFERATION BY THE BONE MARROW MICROENVIRONMENT
    Pinho, Sandra
    EXPERIMENTAL HEMATOLOGY, 2023, 124 : S28 - S28
  • [7] Nucleophosmin, a critical regulator of cell proliferation, is overexpressed in prostate cancer
    Nigwekar, P.
    Wu, C.
    Yao, J. L.
    Bourne, P. A.
    Li, J.
    Zhuang, Z.
    di Sant Agnese, P. A.
    Walters, D. C.
    Huang, J.
    MODERN PATHOLOGY, 2007, 20 : 166A - 167A
  • [8] Survivin is a Mechanosensitive Regulator of Vascular Smooth Muscle Cell Proliferation
    Biber, John C.
    Bae, Yongho
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 250A - 250A
  • [9] Selective Activation and Proliferation of a Unique Stem Cell Population in the Neuroepithelial Body Microenvironment by Transient Acute Lung Injury
    Verckist, Line
    Rottiers, Carmen
    Lembrechts, Robrecht
    Pintelon, Isabel
    Timmermans, Jean-Pierre
    Brouns, Inge
    Adriaensen, Dirk
    FASEB JOURNAL, 2016, 30
  • [10] Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle
    Fukuda, Sumiaki
    Kaneshige, Akihiro
    Kaji, Takayuki
    Noguchi, Yu-taro
    Takemoto, Yusei
    Zhang, Lidan
    Tsujikawa, Kazutake
    Kokubo, Hiroki
    Uezumi, Akiyoshi
    Maehara, Kazumitsu
    Harada, Akihito
    Ohkawa, Yasuyuki
    Fukada, So-ichiro
    ELIFE, 2019, 8
12345