Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

被引:13
|
作者
Moura Estevao, Ligia Reis [1 ]
de Medeiros, Juliana Pinto [2 ]
Simoes, Ricardo Santos [3 ]
Esteves Arantes, Rosa Maria [4 ]
Rachid, Milene Alvarenga [4 ]
Goncalves da Silva, Regildo Marcio [5 ]
Mendonca, Fabio de Souza [6 ]
Evencio-Neto, Joaquim [6 ]
机构
[1] Univ Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Postgrad Program Anim Biosci, BR-52171900 Recife, PE, Brazil
[2] Univ Fed Rural Pernambuco, Dept Morphol & Physiol, Histol Div, BR-52171900 Recife, PE, Brazil
[3] Univ Fed Sao Paulo, Dept Morphol & Genet, Postgrad Program Morphol, Sao Paulo, Brazil
[4] Univ Fed Minas Gerais, Inst Biol Sci, Dept Gen Pathol, Histol Div, Belo Horizonte, MG, Brazil
[5] UNESP, Fac Sci & Letters, Assis, SP, Brazil
[6] Univ Fed Rural Pernambuco, Dept Morphol, Histol Div, BR-52171900 Recife, PE, Brazil
关键词
Wound Healing; Phytotherapy; Mast Cells; Skin; Rats; ANACARDIACEAE; EXTRACTS;
D O I
10.1590/S0102-865020150040000008
中图分类号
R61 [外科手术学];
学科分类号
摘要
PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats. METHODS: Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA - wounds receiving daily topical application of vaseline and lanolin) and treated (LA - wounds treated daily with the topical ointment). The skin region with wounds were collected at days 4, 7, 14 and 21 after surgery. Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. The degree of epithelial contraction was measured and mast cell concentration were also evaluated. RESULTS: The treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively. CONCLUSION: Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.
引用
收藏
页码:289 / 295
页数:7
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