Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway

被引：26
|
作者：
Wang, Wei [1 ,2 ,3 ]
Chen, Renzong [1 ,2 ,3 ]
Wang, Jiye [1 ,2 ,3 ]
机构：
[1] Peoples Hosp Tiantai, Dept Emergency, Tiantai, Peoples R China
[2] Peoples Hosp Tiantai, Dept Gen Practice, Tiantai, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Dept Hepatopancreat & Microinvas Surg, Hangzhou, Zhejiang, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 493卷 / 01期
关键词：
Procyanidin B2; Chronic nonbacterial prostatitis; Anti-inflammatory; Oxidative stress; Nrf2; OXIDATIVE STRESS; NEUROLOGICAL DEFICITS; INSULIN-RESISTANCE; IN-VIVO; GLUTATHIONE; MECHANISMS; EXTRACT; INJURY; MICE;
D O I：
10.1016/j.bbrc.2017.08.089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prostatitis is one of the most prevalent problems in andriatry and urinary surgery. In the present study, we evaluated the effect of procyanidin B2 (PB) on carrageenan-induced chronic nonbacterial prostatitis in rats. Results showed that PB significantly decreased the prostatic index and enhanced the body weight inhibited by carrageenan. Biochemical results revealed that PB significantly lowered the prostatic specific antigen (PSA) and alleviated oxidative stress in serum. The levels of TNF-alpha, IL-6, and IL-10 in prostatic homogenate were also significantly decreased after PB treatment. We also found evidence that PB treatment reversed the suppression of Nrf2 nuclear translocation, and increased the expressions of NQO1 and HO-1 in the prostate glands. In conclusion, treatment with PB attenuates carrageenan-induced chronic nonbacterial prostatitis via anti-inflammatory and activation of the Nrf2 pathway. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：794 / 799
页数：6
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