Linkage disequilibrium mapping of quantitative-trait loci by selective genotyping

被引:40
|
作者
Chen, ZH
Zheng, G
Ghosh, K
Li, ZH
机构
[1] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117543, Singapore
[2] NHLBI, Div Epidemiol & Clin Applicat, Off Biostat Res, Bethesda, MD 20892 USA
[3] George Washington Univ, Dept Stat, Washington, DC USA
[4] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv,NIH, Washington, DC USA
关键词
D O I
10.1086/491658
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.
引用
收藏
页码:661 / 669
页数:9
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