Pertussis vaccination during pregnancy: Antibody persistence in infants

被引：28

作者：

Vilajeliu, Alba ^{[1
,2
]}

Ferrer, Laia ^{[3
,4
]}

Munros, Jordina ^{[3
,4
]}

Gonce, Anna ^{[3
,4
]}

Lopez, Marta ^{[3
,4
]}

Costa, Josep ^{[3
,4
,5
]}

Bayas, Jose M. ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, Dept Prevent Med & Epidemiol, Barcelona, Spain

[2] Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain

[3] Univ Barcelona, Hosp Clin, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Dept Maternal Fetal Med, Barcelona, Spain

[4] Univ Barcelona, Hosp Sant Joan de Deu, Barcelona, Spain

[5] Univ Barcelona, Hosp Clin IDIBAPS, Dept Microbiol, Barcelona, Spain

来源：

VACCINE | 2016年 / 34卷 / 33期

关键词：

Maternal vaccination; Neonatal pertussis; Antibody persistence; Infant vaccination; BORDETELLA-PERTUSSIS; TDAP IMMUNIZATION; YOUNG INFANTS; TETANUS-DIPHTHERIA; NEWBORN; PROTECTION; VACCINES; SAFETY; TRIAL;

D O I：

10.1016/j.vaccine.2016.05.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Maternal pertussis vaccination is associated with higher levels of pertussis antibodies at birth. We assessed the persistence of pertussis antibodies until primary vaccination in infants whose mothers received Tdap (tetanus, diphtheria, acellular pertussis) vaccine during pregnancy. Infants were born at the Hospital Clinic of Barcelona (Spain) in November 2014. Anti-PT IgG was determined by ELISA at delivery, between the first and second month of life, and estimated at 2 months of age. The study included 37 infants whose mothers received Tdap between 21 and 38 weeks of gestation. Infants presented a decline in GMC of anti-PT IgG between peripartum and follow-up levels, 52.7 (95% CI 34.7-80.2) versus 7.5 (95% CI 4.2-13.3) at 2 months of age (p < 0.001). The median half-life of maternal antibodies was 47 days. More than half (51.4%) the infants presented detectable anti-PT IgG before the start of primary infant vaccination. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3719 / 3722

页数：4

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