Application of aptamers in regenerative medicine

被引：8
|
作者：
Luo, Zhaohui [1 ,2 ]
Chen, Shimin [3 ,4 ]
Zhou, Jing [1 ]
Wang, Chong [5 ]
Li, Kai [6 ]
Liu, Jia [2 ]
Tang, Yujin [2 ]
Wang, Liqiang [7 ]
机构：
[1] Youjiang Med Univ Nationalities, Baise, Guangxi, Peoples R China
[2] Youjiang Med Univ Nationalities, Guangxi Biomed Mat Engn Res Ctr Bone & Joint Degen, Dept Orthoped, Guangxi Key Lab basic & translat Res Bone & Joint, Baise, Guangxi, Peoples R China
[3] Guangxi Bot Garden Med Plants, Nanning, Peoples R China
[4] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
[5] Dongguan Univ Technol, Sch Mech Engn, Dongguan, Guangdong, Peoples R China
[6] Southern Med Univ, Acad Orthoped, Guangdong Prov Key Lab Bone & Joint Degenerat Dis, Affiliated Hosp 3, Guangzhou, Peoples R China
[7] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai, Peoples R China
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷
基金：
中国国家自然科学基金;
关键词：
aptamer; tissue regeneration; regenerative medicine; repair of tissue injury; transformation and application; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; DNA APTAMER; CAPTURE MOLECULES; TARGETING APTAMER; TNF-ALPHA; IDENTIFICATION; REMYELINATION; RECRUITMENT; SCAFFOLD;
D O I：
10.3389/fbioe.2022.976960
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Regenerative medicine is a discipline that studies how to use biological and engineering principles and operation methods to repair and regenerate damaged tissues and organs. Until now, regenerative medicine has focused mainly on the in-depth study of the pathological mechanism of diseases, the further development and application of new drugs, and tissue engineering technology strategies. The emergence of aptamers has supplemented the development methods and types of new drugs and enriched the application elements of tissue engineering technology, injecting new vitality into regenerative medicine. The role and application status of aptamers screened in recent years in various tissue regeneration and repair are reviewed, and the prospects and challenges of aptamer technology are discussed, providing a basis for the design and application of aptamers in long-term transformation.
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页数：13
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