Research Progress on Natural Product Ingredients' Therapeutic Effects on Parkinson's Disease by Regulating Autophagy

被引：7
|
作者：
Li, Sicong [1 ]
Sun, Xu [2 ]
Bi, Lei [3 ]
Tong, Yujia [4 ]
Liu, Xin [3 ]
机构：
[1] Peking Univ Hlth Sci Ctr, Sch Pharm, Beijing, Peoples R China
[2] Guangzhou Univ Tradit Chinese Med, Dept Pharm, Affiliated Hosp 1, Guangzhou, Peoples R China
[3] Beijing Univ Tradit Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China
[4] Chinese Acad Med Sci Peking Union Med Coll, Inst Med Informat, Beijing, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷
关键词：
ASTRAGALOSIDE-IV; ALPHA-SYNUCLEIN; BETA-ASARONE; MUCUNA-PRURIENS; OXIDATIVE STRESS; PC12; CELLS; SIGNALING PATHWAY; INDUCED APOPTOSIS; ISCHEMIC-STROKE; MOUSE MODEL;
D O I：
10.1155/2021/5538200
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and older adults. Abnormal proteins such as alpha-synuclein are essential factors in PD's pathogenesis. Autophagy is the main participant in the clearance of abnormal proteins. The overactive or low function of autophagy leads to autophagy stress. Not only is it difficult to clear abnormal proteins but also it can cause damage to neurons. In this article, the effects of natural products ingredients, such as salidroside, paeoniflorin, curcumin, resveratrol, corynoxine, and baicalein, on regulating autophagy and protecting neurons were discussed in detail to provide a reference for the research and development of drugs for the treatment of PD.
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页数：11
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