Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives

被引：0

作者：

Voskoboinik, Olexii Yu. ^{[1
]}

Stavytskyi, Viktor V. ^{[1
]}

Antypenko, Oleksii M. ^{[1
]}

Kazunin, Maksym S. ^{[1
]}

Kravtsov, Dmytro V. ^{[1
]}

Shishkina, Svetlana V. ^{[2
]}

Kovalenkoa, Sergiy I.

机构：

[1] Zaporizhzhia State Med Univ, Dept Organ & Bioorgan Chem, Zaporizhzhia, Ukraine

[2] Natl Acad Sci Ukraine, SSI Inst Single Crystals, Kharkiv, Ukraine

来源：

SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 13期

关键词：

2-[Azolyl-(azinyl-)]anilines; polycyclic heterocycles; pyrido[1; 2-a]quinazolines; tandem reaction; X-ray study; QUINAZOLINES;

D O I：

10.1080/00397911.2020.1762223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Present manuscript describes the synthesis and molecular structure features of novel condensed pyrido[1,2-a]quinazolines. The above-mentioned compounds were synthesized via condensation of 2-[azolyl-(azinyl-)]anilines with 5-oxohexanoic acid. The tandem condensation intermediates were isolated and cyclized under various conditions. The structures of synthesized compounds were confirmed by LC-MS and NMR-spectroscopy. The existence of the substituted pyrido[1,2-a][1,2,4]triazolo[1,5-c]quinazolines molecules as superposition of two resonance structures was detected by the X-Ray analysis.

引用

页码：2043 / 2051

页数：9

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